Last year, the six-time Olympic cycling champion was diagnosed with two to four years to live.
Macmillan said Sir Chris, 48, had shown “incredible courage” in sharing his experience, adding that it would “inspire others who may be facing a similar situation”.
The cancer charity’s chief nursing officer said “a lot of parents will relate” to his experience.
Sir Chris said in an interview with the Sunday Times: “You know, we’re all born and we all die and that’s just part of the process.
“You remind me, am I not lucky that there is a drug I can take that will stave this off as long as possible?”
Macmillan said it hoped Sir Chris “being so open about his diagnosis” would encourage more people living with cancer to reach out for support and urged anyone worried about potential signs or symptoms of cancer to see your GP.
The charity said search engine figures showed a “surge in overall UK online cancer searches” on Sunday.
It added that it was the most seen since March, when the Princess of Wales revealed she had been diagnosed with cancer, and February 2024, when it was announced the King had cancer.
Macmillan said it had 31,000 hits on its website on Sunday, adding that this was 34% more than the average number for Sundays over the past 12 months.
Claire Taylor, chief nurse at Macmillan Cancer Support, said: “Receiving an advanced cancer diagnosis is a life-changing moment for anyone and our thoughts are with Sir Chris Hoy and his family at this difficult time.
“The incredible courage he has shown in sharing this very personal experience will inspire others who may be facing a similar situation and encourage more people to seek support.”
“Everyone’s experience with cancer is different, and it’s important to have open conversations with your healthcare professional and those around you about the impact a diagnosis can have.
“When it comes to talking to children about cancer, it can feel even more daunting and many parents will be contacting Sir Chris as he navigates this.”