Jay Stansfield and Ayumu Yokoyama each scored twice Birmingham City advanced to the EFL Trophy with a 7-1 win Fulham Under 21 years old.
Alfie May, Keshi Anderson and Lyndon Dykes also got in on the action as the Blues really heated up the visitors in the second half, although Martial Godot initially equalised.
Doncaster Rovers secured their progression to the knockout stages of the competition after a win Barnsley 3-1 at the Eco-Power Stadium.
Second-half goals from Joe Ironside and Harry Clifton put the hosts in control before Aidan Marsh halved the deficit. Kyle Hunt sealed the win six minutes from time.
Exeter City maintained their 100% record to progress from Group O with a 3-2 win over Bristol Rovers thanks to goals from Jay Bird, Milenik Alli and Demetri Mitchell. Conor Taylor and Isaac Hutchinson were brought in for Rovers.
AFC Wimbledon also went through despite losing 3-0 at home to Brighton and Hove Albion The U21s who won thanks to second half strikes from Caylan Vickers, Cameron Peupion and Remeiro Moulton.
Manchester City The U21s were the only top-flight youth team to come out on top as they beat Grimsby Town 5-4 on penalties after goals from Reagan Heskey and Danny Rose in the last few minutes could not separate the sides.
There were comprehensive victories for both Mansfield Town and Cheltenham Townwho won Newcastle United and West Ham United U21s 3-0 and 3-2 respectively.
Lucas Aikins and Ben Quinn, who scored twice, helped Mansfield to victory, while Liam Dulson, Matt Taylor and Tom King scored for Cheltenham and Kamarai Simon-Swire grabbed a consolation for the Hammers.
Myles Leaburn scored in each half to help Charlton Athletic took a huge step towards progress with a 3-0 win Chelsea Under 21s before Tyrese Campbell added a third in stoppage time.
Accrington Stanley celebrated a narrow 2-1 victory Everton U21s, with goals courtesy of Charlie J Whittaker and Josh Woods either side of Harrison Armstrong’s equaliser.