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Louisville vs. Clemson Prediction, Odds & Key Players to Watch for College Football Week 10 – Sports Illustrated

Louisville’s seventh straight game is in Death Valley at night against ACC championship favorite Clemson on Saturday night in Week 10 action.

Although the Cardinals have had a tendency to compete against high-profile opponents, the team could face a buzzer beater against Clemson, at least in the eyes of the oddsmakers. Can the Tigers come off their bye week and win by double digits against a gassed Louisville team?

Here’s our betting preview for this ACC showdown.

Distribution

Money line

Total: 60.5 (Over -114/Under -106)

Odds provided by FanDuel Sportsbook

Louisville

Tyler Shaw: Shough had his first really solid season in college football and showed up with the likes of Ja’Corey Brooks giving him weapons on the field. Shaw is in the top 10 in passing this season with 20 touchdowns to just five interceptions. Outside of Georgia, this will be the best offense Clemson has faced, can the Cardinals play spoiler to the Tigers’ ACC title hopes?

Clemson

Cade Strawberry: Clemson’s offense is on fire after the opening weekend loss to Georgia. The Tigers have scored 40 or more goals in all but one game since that loss, and Strawberry continues to look sharp under center. He has passed for 1,836 yards with 24 total touchdowns to just three interceptions.

The Tigers offense hasn’t slowed down since Week 1, and I don’t expect that to happen in Week 10.

Clemson is averaging 48 points per game over its last six games, and Louisville’s defense is steaming, playing in its seventh straight game, and starting to show cracks in the big-play department. The Cardinals are outside the top 100 in both explosive passing and rushing yards this season, which could allow the Tigers to move the ball with ease on offense.

Although Louisville has been competitive this season, I believe this game is the end of a rough stretch of football and that the team won’t have the energy to handle Clemson’s explosive offense, which is tops in EPA/Play and averages nearly four driving points.

Look for the Tigers to get back on offense and target the overall team.

PICK: Clemson team total OVER 35.5

Game odds are updated periodically and are subject to change.

Follow Reed on Twitter @ReedWallach and get all his college football bets betstamp @rw33

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